Reaction Details Report a problem with these data
Target
Polyphenol oxidase 1
Ligand
BDBM233166
Substrate
n/a
Meas. Tech.
In Vitro Tyrosinase Inhibition Assay
pH
6.8±n/a
Temperature
298.15±n/a K
IC50
1.483e+4± 1.01e+3 nM
Comments
extracted
Citation
 Khan, SB; Hassan Khan, MT; Jang, ES; Akhtar, K; Seo, J; Han, H Tyrosinase inhibitory effect of benzoic acid derivatives and their structure-activity relationships. J Enzyme Inhib Med Chem 25:812-7 (2010) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 1
Synonyms:
PPO1 | PPO1_AGABI | Polyphenol oxidase | Tyrosinase
Type:
Enzyme
Mol. Mass.:
63902.83
Organism:
Agaricus bisporus (White button mushroom)
Description:
Q00024
Residue:
568
Sequence:
MSHLLVSPLGGGVQPRLEINNFVKNDRQFSLYVQALDRMYATPQNETASYFQVAGVHGYPLIPFDDAVGPTEFSPFDQWTGYCTHGSTLFPTWHRPYVLILEQILSGHAQQIADTYTVNKSEWKKAATEFRHPYWDWASNSVPPPEVISLPKVTITTPNGQKTSVANPLMRYTFNSVNDGGFYGPYNQWDTTLRQPDSTGVNAKDNVNRLKSVLKNAQASLTRATYDMFNRVTTWPHFSSHTPASGGSTSNSIEAIHDNIHVLVGGNGHMSDPSVAPFDPIFFLHHANVDRLIALWSAIRYDVWTSPGDAQFGTYTLRYKQSVDESTDLAPWWKTQNEYWKSNELRSTESLGYTYPEFVGLDMYNKDAVNKTISRKVAQLYGPQRGGQRSLVEDLSNSHARRSQRPAKRSRLGQLLKGLFSDWSAQIKFNRHEVGQSFSVCLFLGNVPEDPREWLVSPNLVGARHAFVRSVKTDHVAEEIGFIPINQWIAEHTGLPSFAVDLVKPLLAQGLQWRVLLADGTPAELDSLEVTILEVPSELTDDEPNPRSRPPRYHKDITHGKRGGCREA
  
Inhibitor
Name:
BDBM233166
Synonyms:
3-Methyl-2-butenyl-4-hydroxybenzoate (2)
Type:
Small organic molecule
Emp. Form.:
C12H14O3
Mol. Mass.:
206.2378
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#8]-[#6](=O)-c1ccc(-[#8])cc1
Structure:
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