Target
Isocitrate lyase
Ligand
BDBM233188
Substrate
n/a
Meas. Tech.
ICL Enzyme Assay
Temperature
310.15±0 K
IC50
<1.745e+5±n/a nM
Citation
 Sriram, DYogeeswari, PSenthilkumar, PNaidu, GBhat, P 5-Nitro-2,6-dioxohexahydro-4-pyrimidinecarboxamides: synthesis, in vitro antimycobacterial activity, cytotoxicity, and isocitrate lyase inhibition studies. J Enzyme Inhib Med Chem 25:765-72 (2010) [PubMed]  Article 
Target
Name:
Isocitrate lyase
Synonyms:
ACEA_MYCTU | Isocitrase | Isocitratase | Isocitrate lyase | Isocitrate lyase (ICL) | icl
Type:
Enzyme
Mol. Mass.:
47072.93
Organism:
Mycobacterium tuberculosis
Description:
P9WKK7
Residue:
428
Sequence:
MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGSTEEGQFH
  
Inhibitor
Name:
BDBM233188
Synonyms:
N-(5-Bromo-2-pyridinyl)-5-nitro-2,6-dioxohexahydro-4-pyrimidinecarboxamide (3e)
Type:
Small organic molecule
Emp. Form.:
C10H8BrN5O5
Mol. Mass.:
358.105
SMILES:
[O-][N+](=O)C1C(NC(=O)NC1=O)C(=O)Nc1ccc(Br)cn1
Structure:
Search PDB for entries with ligand similarity: