Reaction Details Report a problem with these data
Target
Neuromedin-K receptor
Ligand
BDBM233265
Substrate
n/a
Meas. Tech.
[3H]SR142801 Competition Binding Assay
pH
7.4±n/a
Temperature
277.15±n/a K
Ki
2±n/a nM
Comments
extracted
Citation
 Knust, H; Koblet, A; Nettekoven, M; Ratni, H; Riemer, C; Vifian, W Pyrrolidine compounds US Patent  US9346786 Publication Date 5/24/2016 
Target
Name:
Neuromedin-K receptor
Synonyms:
NK-3 receptor | NK-3R | NK3R | NK3R_HUMAN | NKR | Neurokinin 3 receptor | Neurokinin B receptor | Neurokinin-3 (NK-3) | Neuromedin-3 receptor (NK-3R) | Neuromedin-3 receptor (NK3) | Neuromedin-K receptor | Neuromedin-K receptor (NK-3 receptor) | Neuromedin-K receptor (NK3) | Neuromedin-K receptor(NK3R) | TAC3R | TACR3 | Tachykinin receptor 3 | Tachykinin receptor 3 (NK3)
Type:
Enzyme
Mol. Mass.:
52221.96
Organism:
Homo sapiens (Human)
Description:
P29371
Residue:
465
Sequence:
MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGLPVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADTTRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
  
Inhibitor
Name:
BDBM233265
Synonyms:
US9346786, 69
Type:
Small organic molecule
Emp. Form.:
C30H33ClF3N3O4
Mol. Mass.:
592.049
SMILES:
CCN([C@@H]1CN(C[C@H]1c1ccc(Cl)c(F)c1)C(=O)C1CCN(CC1)C(=O)C1CC(F)C1)C(=O)Oc1ccc(F)cc1 |r,wU:7.8,wD:3.2,(6.08,.05,;5.31,-1.28,;3.77,-1.28,;3,.05,;1.46,.05,;.99,1.51,;2.23,2.42,;3.48,1.51,;4.97,1.91,;6.06,.82,;7.54,1.22,;7.94,2.71,;9.43,3.11,;6.85,3.8,;7.25,5.29,;5.37,3.4,;-.5,1.91,;-.9,3.4,;-1.59,.82,;-1.19,-.66,;-2.28,-1.75,;-3.77,-1.35,;-4.16,.13,;-3.08,1.22,;-4.86,-2.44,;-4.46,-3.93,;-6.34,-2.04,;-7.11,-.71,;-8.45,-1.48,;-9.93,-1.08,;-7.68,-2.81,;3,-2.62,;1.46,-2.62,;3.77,-3.95,;5.31,-3.95,;6.08,-2.62,;7.62,-2.62,;8.39,-3.95,;9.93,-3.95,;7.62,-5.29,;6.08,-5.29,)|
Structure:
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