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Target
Mitogen-activated protein kinase 1
Ligand
BDBM233415
Substrate
n/a
Meas. Tech.
Active ERK2 (aERK) Assay
IC50
2.0±n/a nM
Citation
 Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Indazole derivatives useful as ERK inhibitors US Patent  US9351965 Publication Date 5/31/2016 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERT1 | Erk2 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK2) | MAP kinase 1 | MAP kinase 2 | MAP kinase ERK2 | MAPK 1 | MAPK 2 | MK01_MOUSE | Mapk | Mapk1 | Mitogen-activated protein kinase 2 | Prkm1 | p42 | p42-MAPK
Type:
Protein
Mol. Mass.:
41278.65
Organism:
Mus musculus (Mouse)
Description:
P63085
Residue:
358
Sequence:
MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM233415
Synonyms:
US9351965, 22
Type:
Small organic molecule
Emp. Form.:
C28H29FN4O3
Mol. Mass.:
488.5533
SMILES:
COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r|
Structure:
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