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Target
Tyrosine-protein kinase SYK
Ligand
BDBM233666
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence (HTRF) Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
6.5±n/a nM
Comments
extracted
Citation
 Haidle, AM; Burch, J; Guay, D; Gauthier, JY; Robichaud, J; Fournier, JF; Ellis, JM; Christopher, M; Kattar, SD; Smith, GF; Northrup, AB Substituted phenyl-Spleen Tyrosine Kinase (Syk) inhibitors US Patent  US9353066 Publication Date 5/31/2016 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM233666
Synonyms:
US9353066, 1.119
Type:
Small Organic Molecule
Emp. Form.:
C27H31N3O3
Mol. Mass.:
445.5533
SMILES:
Cc1cc(Nc2nccc(C)n2)cc(c1)-c1ccc(cc1)C(C)(O)[C@H]1CC[C@@H](CC1)C(O)=O |r,wU:27.33,wD:24.26,(4,-11.55,;2.67,-10.78,;1.33,-11.55,;,-10.78,;-1.33,-11.55,;-1.33,-13.09,;,-13.86,;,-15.4,;-1.33,-16.17,;-2.67,-15.4,;-4,-16.17,;-2.67,-13.86,;,-9.24,;1.33,-8.47,;2.67,-9.24,;1.33,-6.93,;2.67,-6.16,;2.67,-4.62,;1.33,-3.85,;,-4.62,;,-6.16,;1.33,-2.31,;-.21,-2.31,;2.87,-2.31,;1.33,-.77,;2.67,,;2.67,1.54,;1.33,2.31,;,1.54,;;1.33,3.85,;2.67,4.62,;,4.62,)|
Structure:
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