Reaction Details Report a problem with these data
Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM50439662
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.4±n/a
IC50
84±n/a nM
Comments
extracted
Citation
 Piomelli, D; Bandiera, T; Mor, M; Tarzia, G; Bertozzi, F; Ponzano, S Disubstituted beta-lactones as inhibitors of N-acylethanolamine acid amidase (NAAA) US Patent  US9353075 Publication Date 5/31/2016 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | Asahl | N-acylethanolamine acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase | N-acylethanolamine-hydrolyzing acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase subunit alpha | N-acylethanolamine-hydrolyzing acid amidase subunit beta | N-acylsphingosine amidohydrolase-like | NAAA_RAT | Naaa
Type:
Enzyme
Mol. Mass.:
40306.53
Organism:
Rattus norvegicus (Rat)
Description:
Q5KTC7
Residue:
362
Sequence:
MGTPAIRAACHGAHLALALLLLLSLSDPWLWATAPGTPPLFNVSLDAAPELRWLPMLQHYDPDFVRAAVAQVIGDRVPQWILEMIGEIVQKVESFLPQPFTSEIRGICDYLNLSLAEGVLVNLAYEASAFCTSIVAQDSQGRIYHGRNLDYPFGNALRKLTADVQFVKNGQIVFTATTFVGYVGLWTGQSPHKFTISGDERDKGWWWENMIAALSLGHSPISWLIRKTLTESEDFEAAVYTLAKTPLIADVYYIVGGTSPQEGVVITRDRGGPADIWPLDPLNGAWFRVETNYDHWEPVPKRDDRRTPAIKALNATGQAHLSLETLFQVLSVFPVYNNYTIYTTVMSAAEPDKYMTMIRNPS
  
Inhibitor
Name:
BDBM50439662
Synonyms:
CHEMBL2419821 | US9353075, 4
Type:
Small organic molecule
Emp. Form.:
C14H17NO4
Mol. Mass.:
263.2891
SMILES:
C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: