Target
Guanylate cyclase soluble subunit alpha-1/beta-1
Ligand
BDBM234188
Substrate
n/a
Meas. Tech.
Homogeneous Time Resolved Fluorescence Assay
Temperature
298.15±n/a K
EC50
3±n/a nM
Comments
extracted
Citation
 Brenneman, JBGinn, JDHopkins, TDLowe, MDSarko, CRWestbrook, JAYu, MZhang, Z Heterocyclic carboxylic acids as activators of soluble guanylate cyclase US Patent  US9353090 Publication Date 5/31/2016 
Target
Name:
Guanylate cyclase soluble subunit alpha-1/beta-1
Synonyms:
Soluble Guanylate Cyclases | Soluble guanylate cyclase (sGC) | Soluble guanylate cyclase alpha 1 and beta 1 subunits (sGC) | Soluble guanylate cyclase alpha1/beta1 complex | soluble guanylate cyclase activators | soluble guanylate cyclase apha 1 and soluble guanylate cyclase beta 1
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Guanylate cyclase soluble subunit alpha-1
Synonyms:
GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC)
Type:
Enzyme
Mol. Mass.:
77457.21
Organism:
Homo sapiens (Human)
Description:
Q02108
Residue:
690
Sequence:
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID
  
Component 2
Name:
Guanylate cyclase soluble subunit beta-1
Synonyms:
GCYB1_HUMAN | GUC1B3 | GUCSB3 | GUCY1B1 | GUCY1B3 | Guanylate cyclase soluble (GCS-beta-1) | Solube guanylate cyclase beta-1 (sGCβ1) | soluble guanylate cyclase beta-1 (sGC)
Type:
Enzyme
Mol. Mass.:
70496.05
Organism:
Homo sapiens (Human)
Description:
Q02153
Residue:
619
Sequence:
MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETKQDDD
  
Inhibitor
Name:
BDBM234188
Synonyms:
US9353090, 321
Type:
Small organic molecule
Emp. Form.:
C31H36ClN3O5S
Mol. Mass.:
598.153
SMILES:
CO[C@H]1CN(CC[C@H]1C(O)=O)c1nc(cs1)-c1cccc(Cl)c1OCc1ccc2CCN(C[C@H](C)c2c1)C1COC1 |r|
Structure:
Search PDB for entries with ligand similarity: