Reaction Details Report a problem with these data
Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Ligand
BDBM234205
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±n/a
IC50
>205000±n/a nM
Comments
extracted
Citation
 Lin, H; He, B Methods of treatment using modulators of SIRT2 US Patent  US9359293 Publication Date 6/7/2016 
Target
Name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:
NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:
Protein
Mol. Mass.:
43582.69
Organism:
Homo sapiens (Human)
Description:
Q9NTG7
Residue:
399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
  
Inhibitor
Name:
BDBM234205
Synonyms:
US9359293, TA
Type:
Small organic molecule
Emp. Form.:
C21H25N3O3S
Mol. Mass.:
399.507
SMILES:
CC(=S)NCCCCC(NC(=O)Oc1ccccc1)C(=O)Nc1ccccc1
Structure:
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