Reaction Details Report a problem with these data
Target
Epidermal growth factor receptor [645-1186]
Ligand
BDBM50340677
Substrate
n/a
Meas. Tech.
EGFR Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
320±n/a nM
Comments
extracted
Citation
 Zhu, ZW; Shi, L; Ruan, XM; Yang, Y; Li, HQ; Xu, SP; Zhu, HL Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives: potent inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase. J Enzyme Inhib Med Chem 26:37-45 (2011) [PubMed]  Article 
Target
Name:
Epidermal growth factor receptor [645-1186]
Synonyms:
EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) | HER1
Type:
Protein
Mol. Mass.:
60974.10
Organism:
Homo sapiens (Human)
Description:
Human EGFR cytoplasmic domain (645-1186 aa)
Residue:
542
Sequence:
SIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGI
  
Inhibitor
Name:
BDBM50340677
Synonyms:
(5-fluorouracil)5-Fluoro-1H-pyrimidine-2,4-dione | 5 fluorouracil | 5-FU | 5-Florouracil | 5-Fluoro-1H-pyrimidine-2,4-dione | 5-Fluoro-1H-pyrimidine-2,4-dione (5-FU) | 5-Fluoro-1H-pyrimidine-2,4-dione (5-Fluorouracil) | 5-Fluoro-1H-pyrimidine-2,4-dione(5-FU) | 5-Fluoro-1H-pyrimidine-2,4-dione(5-FUra) | 5-Fluoro-1H-pyrimidine-2,4-dione(5-fluoro uracil) | 5-Fluoro-1H-pyrimidine-2,4-dione(5-fluorouracil)(5-FU) | 5-Fluoro-1H-pyrimidine-2,4-dione(5FU) | 5-Fluorouracil | 5-fluoro-uracil | 5-fluoropyrimidine-2,4(1H,3H)-dione | 5-fluorouacil | 5-fluorourasil | 5F-uracil | Adrucil | CHEMBL185 | Carac | Efudex | FLUOROURACIL, 5- | Fluoroplex | Fluracil | Ro-2-9757
Type:
Small organic molecule
Emp. Form.:
C4H3FN2O2
Mol. Mass.:
130.0772
SMILES:
Fc1c[nH]c(=O)[nH]c1=O
Structure:
Search PDB for entries with ligand similarity: