Reaction Details Report a problem with these data
Target
Egl nine homolog 1
Ligand
BDBM292135
Substrate
n/a
Meas. Tech.
Fluorescence polarization (FP) Assay
Temperature
298.15±n/a K
IC50
2200±n/a nM
Comments
extracted
Citation
 Zhou, Y; Cai, S; Wang, G; Jiao, L; Min, P; Jing, Y; Guo, M Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof US Patent  US10100051 Publication Date 10/16/2018 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM292135
Synonyms:
2-(2-(4-cyanophenoxy)-5-hydroxy-8-methyl-1,7-naphthyridine-6-formamido) acetic acid | US10100051, Compound 4
Type:
Small organic molecule
Emp. Form.:
C19H14N4O5
Mol. Mass.:
378.3383
SMILES:
Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc(cc3)C#N)nc12
Structure:
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