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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM234387
Substrate
n/a
Meas. Tech.
Cell-Based Functional Assay (M1)
IC50
>10000±0.0 nM
Citation
 Nirogia, RV; Kambhampati, R; Daulatabad, AV; Gudla, P; Shaikh, M; Achanta, PK; Shinde, AK; Dubey, PK Design, synthesis and pharmacological evaluation of conformationally restricted N-arylsulfonyl-3-aminoalkoxy indoles as a potential 5-HT6 receptor ligands. J Enzyme Inhib Med Chem 26:341-9 (2011) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM234387
Synonyms:
10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b-azaindeno[2,1-a]indene-5,5-Dioxide (8a)
Type:
Small organic molecule
Emp. Form.:
C18H18N2O3S
Mol. Mass.:
342.412
SMILES:
CN(C)CCOc1c2-c3ccccc3S(=O)(=O)n2c2ccccc12
Structure:
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