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Target
Neuraminidase
Ligand
BDBM234434
Substrate
n/a
Meas. Tech.
NA Inhibition Assay
IC50
81100±n/a nM
Citation
 Liu, Y; Zhang, L; Gong, J; Fang, H; Liu, A; Du, G; Xu, W Design, synthesis, and biological activity of thiazole derivatives as novel influenza neuraminidase inhibitors. J Enzyme Inhib Med Chem 26:506-13 (2011) [PubMed]  Article 
Target
Name:
Neuraminidase
Synonyms:
NA | NRAM_I82A7 | Neuraminidase (NA)
Type:
Enzyme
Mol. Mass.:
49917.65
Organism:
Influenza A virus H3N2
Description:
Q67344
Residue:
446
Sequence:
MQIAILVTTVTLHFNQYECDSLADNQVMPCEPIIIERNITEIIYLTNTTIEKEICPKLMEYRNWSRPQCKITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPGKCYQFALGQGTTLDNKHSNDTIHDRIPHRTLLMNELGVPFHLGTRQVCIAWSSSSCHDGKAWLHVCVTGDDKNATASFIYDGRLVDSMGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTRILFIEEGKIVHISPLSGSAQHVEECSCYPRYPSVRCICRDNWKGSNRPIVDINIKDYSIDSRYVCSGLVGDTPRNNDRSSSSDCKNPNNDKGNHGVKGWAFDDGNDVWMGRTISKDSRSGYETFKVIDGWSTPNSKSQINRQVIVDRDNRSGYSGIFSVESKGCINRCFYVELIRGRKQETRVWWTSSSIVVFCGTSGTYGKGSWPDGANINFMPI
  
Inhibitor
Name:
BDBM234434
Synonyms:
(S)-Ethyl 2-(2-(2-(tert-butoxycarbonylamino)-4-(methylthio)butanamido)thiazol-4-yl) acetate (8a)
Type:
Small organic molecule
Emp. Form.:
C17H27N3O5S2
Mol. Mass.:
417.543
SMILES:
CCOC(=O)Cc1csc(NC(=O)[C@H](CCSC)NC(=O)OC(C)(C)C)n1 |r|
Structure:
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