Reaction Details Report a problem with these data
Target
Platelet-derived growth factor subunit B
Ligand
BDBM234580
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.4±n/a
IC50
10±n/a nM
Comments
extracted
Citation
 Boral, S; Malone, TC; Wang, S Indole-1-carboxamides as kinase inhibitors US Patent  US9353093 Publication Date 5/31/2016 
Target
Name:
Platelet-derived growth factor subunit B
Synonyms:
PDGF | PDGF2 | PDGFB | PDGFB_HUMAN | Platelet-derived growth factor subunit B | Platelet-derived growth factor subunit B (PDGFB) | SIS
Type:
Enzyme
Mol. Mass.:
27298.80
Organism:
Homo sapiens (Human)
Description:
P01127
Residue:
241
Sequence:
MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA
  
Inhibitor
Name:
BDBM234580
Synonyms:
US9353093, 2
Type:
Small organic molecule
Emp. Form.:
C25H22N4O4
Mol. Mass.:
442.4666
SMILES:
COC(=O)c1ccc2cc(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)n(C(N)=O)c2c1
Structure:
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