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Target
Fatty acid-binding protein, adipocyte
Ligand
BDBM234700
Substrate
n/a
Meas. Tech.
Time Resolved-Fluorescence Energy Transfer (TR-FRET) Assay
pH
7.5±n/a
IC50
44±n/a nM
Comments
extracted
Citation
 Buettelmann, B; Ceccarelli, SM; Kuehne, H; Kuhn, B; Neidhart, W; Obst Sander, U; Richter, H Non-annulated thiophenylamides US Patent  US9353102 Publication Date 5/31/2016 
Target
Name:
Fatty acid-binding protein, adipocyte
Synonyms:
A-FABP | AFABP | ALBP | Adipocyte lipid-binding protein | FABP4 | FABP4_HUMAN | Fatty acid binding protein adipocyte | Fatty acid-binding protein 4 | Fatty acid-binding protein 4 (FABP4)
Type:
Enzyme
Mol. Mass.:
14719.23
Organism:
Homo sapiens (Human)
Description:
P15090
Residue:
132
Sequence:
MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDVITIKSESTFKNTEISFILGQEFDEVTADDRKVKSTITLDGGVLVHVQKWDGKSTTIKRKREDDKLVVECVMKGVTSTRVYERA
  
Inhibitor
Name:
BDBM234700
Synonyms:
US9353102, 4.6
Type:
Small organic molecule
Emp. Form.:
C19H21N3O3S2
Mol. Mass.:
403.518
SMILES:
Cc1nsc(n1)-c1c(C)c(C)sc1NC(=O)C1=C(C2CCC1CC2)C(O)=O |t:18,(1.1,5.18,;-.23,4.41,;-1.7,4.89,;-2.6,3.64,;-1.7,2.4,;-.23,2.87,;-2.47,1.06,;-3.93,.59,;-5.26,1.36,;-3.93,-.95,;-5.26,-1.72,;-2.47,-1.43,;-1.56,-.18,;-.02,-.18,;.75,-1.52,;-.02,-2.85,;2.29,-1.52,;3.38,-2.61,;4.87,-2.21,;5.26,-.72,;4.18,.37,;2.69,-.03,;4.18,-.43,;3.38,-1.81,;2.98,-4.09,;1.49,-4.49,;4.07,-5.18,)|
Structure:
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