Target
Calcium/calmodulin-dependent protein kinase type II subunit delta
Ligand
BDBM292678
Substrate
n/a
Meas. Tech.
CaMKII Cell-Based Activity
EC50
20.3±n/a nM
Citation
 Elzein, EKalla, RVKoltun, DLi, XParkhill, EQPerry, TSimonovich, SPZablocki, JZiebenhaus, CA Fused heterocyclic compounds as CaM kinase inhibitors US Patent  US10100058 Publication Date 10/16/2018 
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit delta
Synonyms:
CAMK2D | CAMKD | CaM kinase II | CaM kinase II delta | CaMK-II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaMKII subunit delta) | KCC2D_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
56419.78
Organism:
Homo sapiens (Human)
Description:
Q13557
Residue:
499
Sequence:
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI
  
Inhibitor
Name:
BDBM292678
Synonyms:
(S)-N-(2-(diethylamino)propyl)-2-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-6-(3-(trifluoromethyl)-1H-pyrazol-4-yl)isonicotinamide | US10100058, Example 334
Type:
Small organic molecule
Emp. Form.:
C27H27F3N8OS
Mol. Mass.:
568.616
SMILES:
CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)-c1c[nH]nc1C(F)(F)F |r|
Structure:
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