Reaction Details Report a problem with these data
Target
Vascular endothelial growth factor receptor 2 [790-1356]
Ligand
BDBM235392
Substrate
n/a
Meas. Tech.
Inhibition Assay
Temperature
303.15±n/a K
IC50
5.4±n/a nM
Comments
extracted
Citation
 Zhang, D; Zhang, R; Zhong, B; Shih, C Cyclopropanecarboxamido-substitute aromatic compounds as anti-tumor agents US Patent  US9359338 Publication Date 6/7/2016 
Target
Name:
Vascular endothelial growth factor receptor 2 [790-1356]
Synonyms:
FLK1 | KDR | VEGFR2 | VGFR2_HUMAN | Vascular endothelial growth factor receptor 2 (KDR)(790-1356) | Vascular endothelial growth factor receptor 2 (VEGFR2)
Type:
Enzyme
Mol. Mass.:
63329.82
Organism:
Homo sapiens (Human)
Description:
P35968[790-1356]
Residue:
567
Sequence:
KRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV
  
Inhibitor
Name:
BDBM235392
Synonyms:
US9359338, Exe. 002
Type:
Small organic molecule
Emp. Form.:
C22H16ClF4N5O3
Mol. Mass.:
509.841
SMILES:
Fc1ccc(Oc2cc(NC(=O)C3CC3)ncn2)cc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
Structure:
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