Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMonoacylglycerol acyltransferase type 2 (h-MGAT2)
LigandBDBM235217
Substrate/Competitorn/a
Meas. Tech.LCMS Assay
IC50 2±n/a nM
Citation Ahmad, SNegash, LA Dihydropyridinone MGAT2 inhibitors US Patent US9365558 Publication Date 6/14/2016
More Info.:Get all data from this article,  Assay Method
 
Monoacylglycerol acyltransferase type 2 (h-MGAT2)
Name:Monoacylglycerol acyltransferase type 2 (h-MGAT2)
Synonyms:Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | Beta-1,2-N-acetylglucosaminyltransferase II | GNT-II | GlcNAc-T II | MGAT2 | Mannoside acetylglucosaminyltransferase 2 | Monoacylglycerol acyltransferase 2 (MGAT2) | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II | h-MGAT2 (human monoacylglycerol acyltransferase type 2)
Type:n/a
Mol. Mass.:51567.80
Organism:Homo sapiens (Human)
Description:Q10469
Residue:447
Sequence:
MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKNEALAPPLLDAEPARGAGGRGGDHPSV
AVGIRRVSNVSAASLVPAVPQPEADNLTLRYRSLVYQLNFDQTLRNVDKAGTWAPRELVL
VVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAGVNFCPVLQVFFPFS
IQLYPNEFPGSDPRDCPRDLPKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHF
VWERVKILRDYAGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTYSASRSF
YGMADKVDVKTWKSTEHNMGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTVSCLPK
FWKVLVPQIPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNNNKQYMFPETLTISEKFTVV
AISPPRKNGGWGDIRDHELCKSYRRLQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM235217
NameBDBM235217
Synonyms:US9365558, 40
TypeSmall organic molecule
Emp. Form.C27H32F3N3O4S2
Mol. Mass.583.686
SMILESCCCCCCCc1cnc(s1)[C@@]1(CC(=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)c1ccc(C)cc1)C(F)(F)F |r,t:15|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a