Ki Summary

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Target

Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)

Ligand

BDBM135824

Substrate

n/a

Meas. Tech.

TR-FRET-Based Assay

Temperature

303.15±n/a K

IC50

25±n/a nM

Comments

extracted

Citation

Mjalli, AM; Gaddam, B; Polisetti, DR; Kostura, MJ; Guzel, M Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors US Patent US9393245 Publication Date 7/19/2016

More Info.:

Get all data from this article, Assay Method

Target

Name:

Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)

Synonyms:

Type:

Enzyme

Mol. Mass.:

64320.36

Organism:

Homo sapiens (Human)

Description:

Q07343-2

Residue:

564

Sequence:

MKEHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT

Inhibitor

Name:

BDBM135824

Synonyms:

US10085990, Example 127 | US10568888, Example 127 | US8853226, 127 | US9393245, 127 | US9833457, 127

Type:

Small organic molecule

Emp. Form.:

C25H25ClN4O5S

Mol. Mass.:

529.008

SMILES:

COc1cccc2c1ncc1c2n(C2CC[C@@H](CC2)NS(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O |r,wU:16.21,(-4,-5.01,;-2.67,-4.24,;-2.67,-2.7,;-4,-1.93,;-4,-.39,;-2.67,.38,;-1.33,-.39,;-1.33,-1.93,;,-2.7,;1.33,-1.93,;1.33,-.39,;,.38,;,1.92,;-1.33,2.69,;-1.33,4.23,;-2.67,5.01,;-4,4.23,;-4,2.69,;-2.67,1.92,;-5.33,5,;-6.67,4.23,;-8,5,;-7.44,2.9,;-5.9,2.9,;1.33,2.69,;1.33,4.23,;2.67,1.92,;4,2.69,;4,4.23,;5.33,5,;6.67,4.23,;6.67,2.69,;8,1.92,;5.33,1.92,;2.67,.38,;4,-.39,)|

Structure: