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Target
Beta-secretase 1
Ligand
BDBM235635
Substrate
n/a
Meas. Tech.
Biochemical Assay
pH
4.5±0
Temperature
310.15±0 K
IC50
>6.0e+4±n/a nM
Citation
 Ma, L; Yang, Z; Li, C; Zhu, Z; Shen, X; Hu, L Design, synthesis and SAR study of hydroxychalcone inhibitors of human ß-secretase (BACE1). J Enzyme Inhib Med Chem 26:643-8 (2011) [PubMed]  Article 
Target
Name:
Beta-secretase 1
Synonyms:
ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1)
Type:
Protein
Mol. Mass.:
55755.10
Organism:
Homo sapiens (Human)
Description:
P56817
Residue:
501
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
  
Inhibitor
Name:
BDBM235635
Synonyms:
(E)-1-(2,4-dihydroxyphenyl)-3-(2-nitrophenyl)-2-propen-1-one (7)
Type:
Small organic molecule
Emp. Form.:
C15H11NO5
Mol. Mass.:
285.2515
SMILES:
Oc1ccc(C(=O)\C=C\c2ccccc2[N+]([O-])=O)c(O)c1
Structure:
Search PDB for entries with ligand similarity: