Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM235672
Substrate
n/a
Meas. Tech.
Hydratase Activity Assay
IC50
2.64e+4±n/a nM
Citation
 Balaydin, HT; Soyut, H; Ekinci, D; Göksu, S; Beydemir, S; Menzek, A; Sahin, E Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols including natural products. J Enzyme Inhib Med Chem 27:43-50 (2012) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM235672
Synonyms:
(2-bromo-3,4-dihydroxyphenyl)(3,4-dihydroxyphenyl)methanone (6)
Type:
Small organic molecule
Emp. Form.:
C13H9BrO5
Mol. Mass.:
325.112
SMILES:
Oc1ccc(cc1O)C(=O)c1ccc(O)c(O)c1Br
Structure:
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