Reaction Details Report a problem with these data
Target
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Ligand
BDBM141899
Substrate
n/a
Meas. Tech.
In Vitro hDDAH-1 Assay
pH
7.4±0
Temperature
310.15±0 K
Ki
1.3e+4± 2e+3 nM
Citation
 Kotthaus, J; Schade, D; Kotthaus, J; Clement, B Designing modulators of dimethylarginine dimethylaminohydrolase (DDAH): a focus on selectivity over arginase. J Enzyme Inhib Med Chem 27:24-8 (2012) [PubMed]  Article 
Target
Name:
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Synonyms:
DDAH | DDAH1 | DDAH1_HUMAN | Dimethylarginine dimethylaminohydrolase (DDAH-1) | Dimethylarginine dimethylaminohydrolase 1 (DDAH) | Dimethylarginine dimethylaminohydrolase 1 (DDAH) E78A | Dimethylarginine dimethylaminohydrolase 1 (DDAH) L271G | Dimethylarginine dimethylaminohydrolase 1 (DDAH) L30A | Dimethylarginine dimethylaminohydrolase 1 (DDAH1) | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Type:
Protein
Mol. Mass.:
31116.90
Organism:
Homo sapiens (Human)
Description:
O94760
Residue:
285
Sequence:
MAGLGHPAAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTCCSVLINKKVDS
  
Inhibitor
Name:
BDBM141899
Synonyms:
US8921421, L-257 | hDDAH inhibitor, 2a
Type:
Small organic molecule
Emp. Form.:
C9H20N4O3
Mol. Mass.:
232.2801
SMILES:
COCCNC(=N)NCCC[C@H](N)C(O)=O |r|
Structure:
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