Reaction Details Report a problem with these data
Target
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Ligand
BDBM60960
Substrate
n/a
Meas. Tech.
In Vitro hDDAH-1 Assay
pH
7.4±0
Temperature
310.15±0 K
Ki
6.06e+5± 6.6e+4 nM
Citation
 Kotthaus, J; Schade, D; Kotthaus, J; Clement, B Designing modulators of dimethylarginine dimethylaminohydrolase (DDAH): a focus on selectivity over arginase. J Enzyme Inhib Med Chem 27:24-8 (2012) [PubMed]  Article 
Target
Name:
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Synonyms:
DDAH | DDAH1 | DDAH1_HUMAN | Dimethylarginine dimethylaminohydrolase (DDAH-1) | Dimethylarginine dimethylaminohydrolase 1 (DDAH) | Dimethylarginine dimethylaminohydrolase 1 (DDAH) E78A | Dimethylarginine dimethylaminohydrolase 1 (DDAH) L271G | Dimethylarginine dimethylaminohydrolase 1 (DDAH) L30A | Dimethylarginine dimethylaminohydrolase 1 (DDAH1) | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Type:
Protein
Mol. Mass.:
31116.90
Organism:
Homo sapiens (Human)
Description:
O94760
Residue:
285
Sequence:
MAGLGHPAAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTCCSVLINKKVDS
  
Inhibitor
Name:
BDBM60960
Synonyms:
hDDAH inhibitor, 2f
Type:
n/a
Emp. Form.:
C8H15F3N4O2
Mol. Mass.:
256.2255
SMILES:
N[C@@H](CCCNC(=N)NCC(F)(F)F)C(O)=O |r|
Structure:
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