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Target
Neuraminidase
Ligand
BDBM5025
Substrate
n/a
Meas. Tech.
Neuraminidase Activity Assay
pH
6.5±0
IC50
23.71±7.2 nM
Citation
 Kongkamnerd, J; Milani, A; Cattoli, G; Terregino, C; Capua, I; Beneduce, L; Gallotta, A; Pengo, P; Fassina, G; Miertus, S; De-Eknamkul, W A screening assay for neuraminidase inhibitors using neuraminidases N1 and N3 from a baculovirus expression system. J Enzyme Inhib Med Chem 27:5-11 (2012) [PubMed]  Article 
Target
Name:
Neuraminidase
Synonyms:
Neuraminidase N1
Type:
Enzyme
Mol. Mass.:
49002.56
Organism:
Influenza A virus (A/turkey/Italy/4426/2000(H7N1))
Description:
A4U6B8
Residue:
447
Sequence:
MNPNQKIITIGSVCIVIGIVSLMLQIGNIISIWVSHSIQTGNQYQPEPCNQSITEQAVTSVTLAGNSSLCPISGWAIYSKDNGIRIGSKGDVFVIREPFISCSYLECRTFFLTQGALLNDKHSNGTVKDRSPYRTLMSCPMGEAPSPYNSRFESVAWSASACHDGISWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKIEKGKVVKSVELNAPNYHYEECSCYPDAGEIMCVCRDNWHGSNRPWVSFNQNLEYQLGYVCSGVFGDNPRPNDGTGNCGPMSSNGAYGVKGFSFKYGNGVWIGRTKSTSSRSGFEMIWDPNGWTETDSNFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSETVGWSWPDGAELPFTIDK
  
Inhibitor
Name:
BDBM5025
Synonyms:
Oseltamivir | US10919856, POSITIVE CONTROL | ethyl (3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C16H28N2O4
Mol. Mass.:
312.4045
SMILES:
[H][C@@]1(OC(CC)CC)C=C(C[C@H](N)[C@H]1NC(C)=O)C(=O)OCC |r,c:8|
Structure:
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