| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 9 (TLR9) |
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| Ligand | BDBM235716 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Antagonism Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 113±n/a nM |
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| Comments | extracted |
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| Citation |  Lipford, GB; Zepp, CM Immune system modulators US Patent US9359361 Publication Date 6/7/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Toll-like receptor 9 (TLR9) |
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| Name: | Toll-like receptor 9 (TLR9) |
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| Synonyms: | Toll-like receptor 9 |
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| Type: | Enzyme |
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| Mol. Mass.: | 115889.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NR96 |
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| Residue: | 1032 |
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| Sequence: | MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAA
PRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFL
AVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY
KNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDL
ANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLN
ASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSF
GSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV
DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLS
RNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHS
FTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSL
RALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRL
RDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGF
FSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAA
VPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCG
WDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRG
RWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLE
DRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHF
YNRNFCQGPTAE
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|
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| BDBM235716 |
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| Name | BDBM235716 |
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| Synonyms: | US10117875, Example 57 | US9359361, 57 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H33N9 |
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| Mol. Mass. | 447.5791 |
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| SMILES | CN1CCN(CCNc2nc(nc3nc(cnc23)N2CCN(C)CC2)-c2ccccc2)CC1 |
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| Structure | 
|
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| n/a |
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