Reaction Details Report a problem with these data
Target
cGMP-specific 3',5'-cyclic phosphodiesterase [537-875]
Ligand
BDBM235766
Substrate
n/a
Meas. Tech.
Caliper Mobility-Shift Assay
pH
7.5±n/a
IC50
17.32±n/a nM
Comments
extracted
Citation
 Wu, F; Wang, A Bicyclic substituted pyrimidine compounds US Patent  US9359371 Publication Date 6/7/2016 
Target
Name:
cGMP-specific 3',5'-cyclic phosphodiesterase [537-875]
Synonyms:
PDE5 | PDE5A | PDE5A_HUMAN | Phosphodiesterase 5A
Type:
Enzyme
Mol. Mass.:
39142.81
Organism:
Homo sapiens (Human)
Description:
Recombinant human PDE5A (537-end O76074); Cat no. 93-31G-20 (SignalChem).
Residue:
339
Sequence:
TRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
  
Inhibitor
Name:
BDBM235766
Synonyms:
US9359371, Avanafil
Type:
Small organic molecule
Emp. Form.:
C23H26ClN7O3
Mol. Mass.:
483.951
SMILES:
COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl |w:7.6,16.17|
Structure:
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