Target
Genome polyprotein [1027-1711]
Ligand
BDBM235868
Substrate
n/a
Meas. Tech.
ELISA-Based Assay
IC50
15.08±n/a nM
Citation
 Dai, XLiu, HPalani, AHe, SNargund, RXiao, DZorn, NDang, QMcComas, CCPeng, XLi, PSoll, R Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases US Patent  US9364482 Publication Date 6/14/2016 
Target
Name:
Genome polyprotein [1027-1711]
Synonyms:
NS3-NS4A Protease | NS3/4A protease | POLG_HCV77
Type:
n/a
Mol. Mass.:
72913.15
Organism:
Hepatitis C virus genotype 1a (strain H77) (HCV)
Description:
amino acids 1027 to 1711
Residue:
685
Sequence:
APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQTYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPTGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMRSPVFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAKGYKVLVLNPSVAATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADAGCSGGAYDIIICDECHSTDATSISGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLGFWEGVFTGLTHIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMRKCLIRLKPTLHGPTPLLYRLGAVQNEVTLTHPITKYIMTCMSADLEVVTSTWVLVGGVLAALAAYCLSTGCVVIVGRIVLSGKPAIIPDREVLYQEFDEMEEC
  
Inhibitor
Name:
BDBM235868
Synonyms:
US9364482, 43
Type:
Small organic molecule
Emp. Form.:
C33H28FN5O6S
Mol. Mass.:
641.669
SMILES:
CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2nnn(C(CO)c3ccccc3)c(=O)c2c1)-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: