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Target
Gamma-aminobutyric acid receptor subunit alpha-4
Ligand
BDBM235899
Substrate
n/a
Meas. Tech.
[35S]-TBPS Displacement Assay
IC50
748±103 nM
Citation
 Covey, D Neuroactive substituted cyclopenta[b]phenanthrenes as modulators for GABA type-A receptors US Patent  US9365502 Publication Date 6/14/2016 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-4
Synonyms:
GBRA4_RAT | Gabra4 | Gamma-aminobutyric acid receptor (GABA(A)) subunit alpha-4
Type:
Enzyme
Mol. Mass.:
60972.37
Organism:
Rattus norvegicus (Rat)
Description:
P28471
Residue:
552
Sequence:
MVSVQKVPAIVLCSGVSLALLHVLCLATCLNESPGQNSKDEKLCPENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMQKAKKKISKPPPEVPAAPVLKEKHTETSLQNTHANLNMRKRTNALVHSESDVNSRTEVGNHSSKTTAAQESSETTPKAHLASSPNPFSRANAAETISAAARGLSSAASPSPHGTLQPAPLRSASARPAFGARLGRIKTTVNTTGVPGNVSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKSESLM
  
Inhibitor
Name:
BDBM235899
Synonyms:
US9365502, MQ-83
Type:
Small organic molecule
Emp. Form.:
C19H30O2
Mol. Mass.:
290.4403
SMILES:
C[C@]12C[C@H]3CC[C@H]4C[C@@H](O)CC[C@@]4(C)[C@@H]3CC1CCC2=O |r|
Structure:
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