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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM162070
Substrate
n/a
Meas. Tech.
Cytoxicity Assay of JeKo1 cell
IC50
4400±n/a nM
Citation
 Webb, TR; Lagisetti, C Anticancer compounds US Patent  US9682993 Publication Date 6/20/2017 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM162070
Synonyms:
US9682993, Table III
Type:
Small organic molecule
Emp. Form.:
C26H40N2O7
Mol. Mass.:
492.605
SMILES:
C[C@H](OC(=O)N(C)C)\C=C/C(=O)N[C@H]1CO[C@@H](C\C=C(/C)\C=C\[C@@H]2C[C@]3(CO3)CC(C)(C)O2)OC1 |r,wU:13.12,16.16,23.22,wD:1.0,25.27,(-10.82,-2.32,;-9.48,-1.55,;-9.48,-.01,;-10.57,1.08,;-12.06,.68,;-10.17,2.57,;-8.69,2.96,;-11.26,3.65,;-8.15,-2.32,;-6.61,-2.32,;-5.28,-1.55,;-5.28,-.01,;-3.94,-2.32,;-2.61,-1.55,;-2.61,-.01,;-1.28,.76,;.06,-.01,;1.39,.76,;2.73,-.01,;4.06,.76,;4.06,2.3,;5.39,-.01,;6.73,.76,;8.06,-.01,;8.06,-1.55,;9.39,-2.32,;10.16,-3.65,;8.62,-3.65,;10.73,-1.55,;10.73,-.01,;12.06,.76,;12.06,-.78,;9.39,.76,;.06,-1.55,;-1.28,-2.32,)|
Structure:
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