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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM162071
Substrate
n/a
Meas. Tech.
Cytoxicity Assay of JeKo1 cell
IC50
>10000±n/a nM
Citation
 Webb, TR; Lagisetti, C Anticancer compounds US Patent  US9682993 Publication Date 6/20/2017 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM162071
Synonyms:
US9682993, Table III
Type:
Small organic molecule
Emp. Form.:
C25H38N2O7
Mol. Mass.:
478.5784
SMILES:
CNC(=O)O[C@@H](C)\C=C/C(=O)N[C@H]1CO[C@@H](C\C=C(/C)\C=C\[C@@H]2C[C@]3(CO3)CC(C)(C)O2)OC1 |r,wU:12.11,15.15,22.21,wD:5.5,24.26,(-8.69,3.31,;-10.17,2.91,;-10.57,1.42,;-12.06,1.02,;-9.48,.33,;-9.48,-1.21,;-10.82,-1.98,;-8.15,-1.98,;-6.61,-1.98,;-5.28,-1.21,;-5.28,.33,;-3.94,-1.98,;-2.61,-1.21,;-2.61,.33,;-1.28,1.1,;.06,.33,;1.39,1.1,;2.73,.33,;4.06,1.1,;4.06,2.64,;5.39,.33,;6.73,1.1,;8.06,.33,;8.06,-1.21,;9.39,-1.98,;10.16,-3.31,;8.62,-3.31,;10.73,-1.21,;10.73,.33,;12.06,1.1,;12.06,-.44,;9.39,1.1,;.06,-1.21,;-1.28,-1.98,)|
Structure:
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