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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM162075
Substrate
n/a
Meas. Tech.
Cytoxicity Assay of JeKo1 cell
IC50
>10000±n/a nM
Citation
 Webb, TR; Lagisetti, C Anticancer compounds US Patent  US9682993 Publication Date 6/20/2017 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM162075
Synonyms:
US9682993, Table III
Type:
Small organic molecule
Emp. Form.:
C24H36N2O7
Mol. Mass.:
464.5518
SMILES:
C[C@H](OC(N)=O)\C=C/C(=O)N[C@H]1CO[C@@H](C\C=C(/C)\C=C\[C@@H]2C[C@]3(CO3)CC(C)(C)O2)OC1 |r,wU:11.10,14.14,21.20,wD:1.0,23.25,(-10.82,-1.78,;-9.48,-1.01,;-9.48,.53,;-10.57,1.62,;-10.17,3.11,;-12.06,1.22,;-8.15,-1.78,;-6.61,-1.78,;-5.28,-1.01,;-5.28,.53,;-3.94,-1.78,;-2.61,-1.01,;-2.61,.53,;-1.28,1.3,;.06,.53,;1.39,1.3,;2.73,.53,;4.06,1.3,;4.06,2.84,;5.39,.53,;6.73,1.3,;8.06,.53,;8.06,-1.01,;9.39,-1.78,;10.16,-3.11,;8.62,-3.11,;10.73,-1.01,;10.73,.53,;12.06,1.3,;12.06,-.24,;9.39,1.3,;.06,-1.01,;-1.28,-1.78,)|
Structure:
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