Reaction Details Report a problem with these data
Target
Urease subunit alpha
Ligand
BDBM50099857
Substrate
n/a
Meas. Tech.
Urease Inhibition Assay
pH
7.4±n/a
Temperature
277.15±n/a K
IC50
4.247e+4± 1.9e+2 nM
Comments
extracted
Citation
 Cui, YM; Dong, XW; Chen, W; Wang, WJ; Li, YG; Zhu, HL Synthesis, inhibitory activity and molecular docking studies of two Cu(II) complexes against Helicobacter pylori urease. J Enzyme Inhib Med Chem 27:528-32 (2012) [PubMed]  Article 
Target
Name:
Urease subunit alpha
Synonyms:
Urease
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Urease subunit alpha
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
26573.32
Organism:
Helicobacter pylori ATCC43504
Description:
I0ZGT1
Residue:
238
Sequence:
MKLTPKELDKLMLHYAGELARKRKEKGIKLNYVEAVALISAHIMEEARAGKKTAAELMQEGRTLLKPDDVMDGVASMIHEVGIEAMFPDGTKLVTVHTPIEANGKLVPGELFLKNEDITINEGKKAVSVKVKNVGDRPVQIGSHFHFFEVNRCLDFDREKTFGKRLDIASGTAVRFEPGEEKSVELIDIGGNRRIFGFNALVDRQADNESKKIALHRAKERGFHGAKSDDNYVKTIKE
  
Component 2
Name:
Urease
Synonyms:
Urease subunit beta
Type:
Enzyme
Mol. Mass.:
29567.71
Organism:
Helicobacter pylori ATCC43504
Description:
I0ZGT0
Residue:
281
Sequence:
MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNTSNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGG
  
Inhibitor
Name:
BDBM50099857
Synonyms:
ACETOHYDROXAMIC ACID (AHA) | AHA | Acethydroxamsaeure | Acethydroxamsaure | Acetic acid, oxime | Acetylhydroxamic acid | Cetohyroxamic acid | Lithostat | Methylhydroxamic acid | N-Acetyl hydroxyacetamide | N-Acetylhydroxylamine | N-Hydroxyacetamide | acetohydroxamic acid
Type:
Small organic molecule
Emp. Form.:
C2H5NO2
Mol. Mass.:
75.0666
SMILES:
CC(=O)NO
Structure:
Search PDB for entries with ligand similarity: