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Target
Mitogen-activated protein kinase 1 [8-360]
Ligand
BDBM236884
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.3±n/a
IC50
2.5±n/a nM
Comments
extracted
Citation
 Blake, J; Chen, H; Chicarelli, M; Gaudino, J; Gazzard, L; Kintz, S; Mohr, P; Robarge, K; Schwarz, J; Zhou, A Serine/threonine kinase inhibitors US Patent  US9388171 Publication Date 7/12/2016 
Target
Name:
Mitogen-activated protein kinase 1 [8-360]
Synonyms:
ERK2 | Human ERK-2 | MAPK1 | MK01_HUMAN | Mitogen Activated Kinase 1 | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (aa 8-360) | PRKM1 | PRKM2
Type:
n/a
Mol. Mass.:
40835.09
Organism:
Homo sapiens (Human)
Description:
P28482 aa 8-360
Residue:
353
Sequence:
GAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM236884
Synonyms:
US9388171, II-2
Type:
Small organic molecule
Emp. Form.:
C24H25ClFN3O2
Mol. Mass.:
441.926
SMILES:
CC[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)cc2c1)c1ccc(Cl)c(F)c1 |r|
Structure:
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