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Target
Histone-lysine N-methyltransferase SMYD3
Ligand
BDBM293364
Substrate
n/a
Meas. Tech.
SMYD3 Biochemical Assay
IC50
853±n/a nM
Citation
 Foley, MA; Kuntz, KW; Mitchell, LH; Munchhof, MJ Substituted isoxazoles for treating cancer US Patent  US10106510 Publication Date 10/23/2018 
Target
Name:
Histone-lysine N-methyltransferase SMYD3
Synonyms:
SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1
Type:
Enzyme
Mol. Mass.:
49101.22
Organism:
Homo sapiens (Human)
Description:
Q9H7B4-2
Residue:
428
Sequence:
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS
  
Inhibitor
Name:
BDBM293364
Synonyms:
N-((1r,4r)-4-((2- aminoethyl)amino) cyclohexyl)-5- cyclopropylisoxazole-3- carboxamide | US10106510, Compound 28
Type:
Small organic molecule
Emp. Form.:
C15H24N4O2
Mol. Mass.:
292.3767
SMILES:
NCCN[C@H]1CC[C@@H](CC1)NC(=O)c1cc(on1)C1CC1 |r,wU:7.10,wD:4.3,(8.73,1.5,;7.4,2.27,;6.07,1.5,;4.73,2.27,;3.4,1.5,;2.07,2.27,;.73,1.5,;.73,-.04,;2.07,-.81,;3.4,-.04,;-.6,-.81,;-1.93,-.04,;-1.93,1.5,;-3.27,-.81,;-4.51,.1,;-5.76,-.81,;-5.28,-2.27,;-3.74,-2.27,;-7.25,-.41,;-8.34,.68,;-8.73,-.81,)|
Structure:
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