Target
E3 ubiquitin-protein ligase XIAP [124-240]
Ligand
BDBM237579
Substrate
n/a
Meas. Tech.
TR-FRET Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
24±n/a nM
Comments
extracted
Citation
 Donnell, AFHan, XKester, RFKong, NLe, KLou, YMichoud, CMoliterni, JARemiszewski, SRupert, KCYun, W Substituted hetero-azepinones US Patent  US9394263 Publication Date 7/19/2016 
Target
Name:
E3 ubiquitin-protein ligase XIAP [124-240]
Synonyms:
API3 | BIRC4 | Baculoviral IAP repeat-containing protein 2 (BIR2) | E3 ubiquitin-protein ligase XIAP (BIR2) | E3 ubiquitin-protein ligase XIAP BIR2 | IAP3 | XIAP | XIAP protein BIR2 | XIAP_HUMAN
Type:
Protein
Mol. Mass.:
13562.46
Organism:
Artificial Sequence
Description:
TR-FRET peptide Corresponds to amino acids 124-240 of human XIAP.
Residue:
117
Sequence:
RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE
  
Inhibitor
Name:
BDBM237579
Synonyms:
US9394263, 1a' | US9394263, 1b'
Type:
Small organic molecule
Emp. Form.:
C28H30BrN3O5
Mol. Mass.:
568.459
SMILES:
CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2O[C@@]11CCOC1 |r|
Structure:
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