Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase XIAP [124-240]
Ligand
BDBM237626
Substrate
n/a
Meas. Tech.
TR-FRET Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
77±n/a nM
Comments
extracted
Citation
 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W Substituted hetero-azepinones US Patent  US9394263 Publication Date 7/19/2016 
Target
Name:
E3 ubiquitin-protein ligase XIAP [124-240]
Synonyms:
API3 | BIRC4 | Baculoviral IAP repeat-containing protein 2 (BIR2) | E3 ubiquitin-protein ligase XIAP (BIR2) | E3 ubiquitin-protein ligase XIAP BIR2 | IAP3 | XIAP | XIAP protein BIR2 | XIAP_HUMAN
Type:
Protein
Mol. Mass.:
13562.46
Organism:
Artificial Sequence
Description:
TR-FRET peptide Corresponds to amino acids 124-240 of human XIAP.
Residue:
117
Sequence:
RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE
  
Inhibitor
Name:
BDBM237626
Synonyms:
US9394263, 38
Type:
Small organic molecule
Emp. Form.:
C26H28BrN3O5
Mol. Mass.:
542.422
SMILES:
COc1ccc2cc(Br)ccc2c1CN1c2ccc(C)cc2OC[C@H](NC(=O)[C@@H](N)[C@H](C)O)C1=O |r|
Structure:
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