Reaction Details Report a problem with these data
Target
Beta-2 adrenergic receptor
Ligand
BDBM238341
Substrate
n/a
Meas. Tech.
cAMP Assay
Temperature
310.15±n/a K
EC50
1±n/a nM
Comments
extracted
Citation
 Hughes, AD; Byun, D; Jacobsen, JR Diamide compounds having muscarinic receptor antagonist and BETA2 adrenergic receptor agonist activity US Patent  US9394275 Publication Date 7/19/2016 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM238341
Synonyms:
US9394275, I-41
Type:
Small organic molecule
Emp. Form.:
C51H56N6O6
Mol. Mass.:
849.0269
SMILES:
CC(Cc1ccc(NC(=O)c2ccc(C)c(c2)N(C)C(=O)CCN2CCC(CC2)OC(=O)Nc2ccccc2-c2ccccc2)cc1)NC[C@H](C)c1ccc(O)c2[nH]c(=O)ccc12 |r|
Structure:
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