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Target
Beta-2 adrenergic receptor
Ligand
BDBM103749
Substrate
n/a
Meas. Tech.
cAMP Assay
Temperature
310.15±n/a K
EC50
1±n/a nM
Comments
extracted
Citation
 Hughes, AD; Byun, D; Jacobsen, JR Diamide compounds having muscarinic receptor antagonist and BETA2 adrenergic receptor agonist activity US Patent  US9394275 Publication Date 7/19/2016 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM103749
Synonyms:
US8551978, I-16 | US8816088, I-16 | US9394275, I-16 | US9572802, Compound I-16 | US9682957, I-16
Type:
Small organic molecule
Emp. Form.:
C46H54N6O8
Mol. Mass.:
818.9564
SMILES:
COc1cc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1NC(=O)CCCCN(C)C(=O)CCN1CCC(CC1)OC(=O)Nc1ccccc1-c1ccccc1 |r|
Structure:
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