Reaction Details Report a problem with these data
Target
Mineralocorticoid receptor [729-984]
Ligand
BDBM238158
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.5±n/a
IC50
740±n/a nM
Comments
extracted
Citation
 O'Mahony, G; Kossenjans, M; Edman, K; Kajanus, J; Hogner, KA; Cornwall, P; Turner, A Benzoxazinone amides as mineralocorticoid receptor modulators US Patent  US9394291 Publication Date 7/19/2016 
Target
Name:
Mineralocorticoid receptor [729-984]
Synonyms:
MCR | MCR_HUMAN | MLR | Mineralocorticoid receptor (MR) | Mineralocorticoid receptor(MR)( (T729-K985) | NR3C2
Type:
Enzyme
Mol. Mass.:
29747.25
Organism:
Homo sapiens (Human)
Description:
amino acids T729-K985
Residue:
256
Sequence:
TISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK
  
Inhibitor
Name:
BDBM238158
Synonyms:
US10017502, Example 4 | US9394291, 4
Type:
Small organic molecule
Emp. Form.:
C20H18FN3O5
Mol. Mass.:
399.3724
SMILES:
CNC(=O)CC1COc2cc(F)ccc2N1C(=O)c1ccc2OCC(=O)Nc2c1
Structure:
Search PDB for entries with ligand similarity: