Reaction Details
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Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Ligand
BDBM238190
Substrate
n/a
Meas. Tech.
Fluorescence Polarization-Based Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
210±40 nM
IC50
1110±220 nM
Comments
extracted
Citation
Nikolovska-Coleska, Z; Abulwerdi, F; Showalter, H; Miao, L; Stuckey, J; Mady, A Small molecule inhibitors of MCL-1 and uses thereof US Patent US9394303 Publication Date 7/19/2016 More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Synonyms:
Bcl-2-related protein EAT/mcl1 | MCL1_MOUSE | Mcl-1 | Mcl1
Type:
Developmental protein
Mol. Mass.:
35215.08
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
331
Sequence:
MFGLRRNAVIGLNLYCGGASLGAGGGSPAGARLVAEEAKARREGGGEAALLPGARVVARPPPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVSPEEELDGCEPEAIGKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGVTNWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
Inhibitor
Name:
BDBM238190
Synonyms:
US9394303, 16
Type:
Small organic molecule
Emp. Form.:
C29H23N3O3
Mol. Mass.:
461.5112
SMILES:
Cc1nn(Cc2ccc(Oc3ccccc3)cc2)c2nc(\C=C\c3ccccc3)cc(C(O)=O)c12
Structure:
