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Target
Epidermal growth factor receptor [668-1210]
Ligand
BDBM238270
Substrate
n/a
Meas. Tech.
Cell Assay
EC50
>1000±n/a nM
Citation
 Lee, K; Niu, D; Baevsky, MF Mutant-selective EGFR inhibitors and uses thereof US Patent  US9409887 Publication Date 8/9/2016 
Target
Name:
Epidermal growth factor receptor [668-1210]
Synonyms:
EGF-R Tyrosine Kinase | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) | HER1 | Receptor tyrosine-protein kinase ErbB-1
Type:
Cytoplasmic region
Mol. Mass.:
61304.06
Organism:
Homo sapiens (Human)
Description:
Wildtype EGFR was purchased from Invitrogen.
Residue:
543
Sequence:
MRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA
  
Inhibitor
Name:
BDBM238270
Synonyms:
US9409887, I-1
Type:
Small organic molecule
Emp. Form.:
C26H27F4N7O2
Mol. Mass.:
545.5319
SMILES:
COc1cc(NC2CN(CCF)C2)ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F
Structure:
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