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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM238810
Substrate
n/a
Meas. Tech.
Homogeneous Time Resolved Fluorescence Assay (HTRF)
pH
7±n/a
Temperature
295.15±n/a K
IC50
0.16±n/a nM
Comments
extracted
Citation
 Cee, V; Chavez, Jr., F; Chen, JJ; Harrington, EH; Herberich, B; Jackson, CL; Lanman, BA; Nguyen, TT; Norman, MH; Pettus, LH; Reed, AB; Smith, AL; Tamayo, NA; Tasker, A; Wang, H; Wu, B; Wurz, R Amides as pim inhibitors US Patent  US9394297 Publication Date 7/19/2016 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM238810
Synonyms:
US9394297, 497
Type:
Small organic molecule
Emp. Form.:
C25H31N7O3
Mol. Mass.:
477.5587
SMILES:
C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2nc(C)c(N[C@H]3CCC[C@H](C3)NC(=O)[C@H](N)CO)nc12
Structure:
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