Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase XIAP [124-240]
Ligand
BDBM238829
Substrate
n/a
Meas. Tech.
TR-FRET Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
21.2±n/a nM
Comments
extracted
Citation
 Hogg, JH; Remiszewski, S; Yun, W Indolines US Patent  US9403768 Publication Date 8/2/2016 
Target
Name:
E3 ubiquitin-protein ligase XIAP [124-240]
Synonyms:
API3 | BIRC4 | Baculoviral IAP repeat-containing protein 2 (BIR2) | E3 ubiquitin-protein ligase XIAP (BIR2) | E3 ubiquitin-protein ligase XIAP BIR2 | IAP3 | XIAP | XIAP protein BIR2 | XIAP_HUMAN
Type:
Protein
Mol. Mass.:
13562.46
Organism:
Artificial Sequence
Description:
TR-FRET peptide Corresponds to amino acids 124-240 of human XIAP.
Residue:
117
Sequence:
RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE
  
Inhibitor
Name:
BDBM238829
Synonyms:
US9403768, 1
Type:
Small organic molecule
Emp. Form.:
C26H32F2N4O3
Mol. Mass.:
486.5541
SMILES:
CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@H](C(=O)Nc2c(F)cccc2F)C(C)(C)c2ccccc12 |r|
Structure:
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