Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase SMURF1 [420-757]
Ligand
BDBM239131
Substrate
n/a
Meas. Tech.
Biochemical Assay
Temperature
298.15±n/a K
IC50
5100±n/a nM
Comments
extracted
Citation
 Bala, KJ; Brearley, A; Dale, J; Edwards, A; Ahmed, M; Porter, D; Pulz, RA; Rooney, LA; Sandham, DA; Shaw, D; Smith, N; Taylor, JL; Taylor, RJ; Troxler, TJ; Wrigglesworth, J Carboxamide derivatives US Patent  US9403810 Publication Date 8/2/2016 
Target
Name:
E3 ubiquitin-protein ligase SMURF1 [420-757]
Synonyms:
HECT-type E3 ubiquitin transferase SMURF1 | KIAA1625 | SMUF1_HUMAN | SMURF1
Type:
Enzyme
Mol. Mass.:
39188.96
Organism:
Homo sapiens (Human)
Description:
HECTdomain amino acid 420-757
Residue:
338
Sequence:
RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
  
Inhibitor
Name:
BDBM239131
Synonyms:
US9403810, 22b
Type:
Small organic molecule
Emp. Form.:
C22H32N4O4
Mol. Mass.:
416.5139
SMILES:
C[C@@H]1CC[C@@H](OC1)c1onc(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)c1C |r|
Structure:
Search PDB for entries with ligand similarity: