Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185]
Ligand
BDBM238904
Substrate
n/a
Meas. Tech.
Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay
Temperature
298.15±n/a K
IC50
14040±n/a nM
Comments
extracted
Citation
Furet, P; Guagnano, V; Holzer, P; Kallen, J; Mah, R; Masuya, K; Schlapbach, A; Vaupel, A Substituted purinone compounds US Patent US9403827 Publication Date 8/2/2016
More Info.:
Target
Name:
E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185]
Synonyms:
p53-MDM4
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
E3 ubiquitin-protein ligase Mdm2 [2-188]
Synonyms:
E3 ubiquitin-protein ligase Mdm2 | MDM2 | MDM2_HUMAN
Type:
Protein
Mol. Mass.:
21187.98
Organism:
Homo sapiens (Human)
Description:
aa 2-188
Residue:
187
Sequence:
CNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDS
Component 2
Name:
Protein Mdm4 [2-185]
Synonyms:
E3 ubiquitin-protein ligase Mdm4 | MDM4 | MDM4_HUMAN | MDMX | p53-binding protein Mdm4
Type:
Protein
Mol. Mass.:
20438.64
Organism:
Homo sapiens (Human)
Description:
aa 2-185
Residue:
184
Sequence:
TSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSR