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Target
Receptor-type tyrosine-protein kinase FLT3 [564-993]
Ligand
BDBM239042
Substrate
BioDB n*24 SEQ ID NO: 1
Meas. Tech.
Biochemical Assay
pH
7.9±n/a
Temperature
301.15±n/a K
IC50
<50±n/a nM
Comments
extracted
Citation
 Lombardi Borgia, A; Ciomei, M; Donati, D; Nesi, M Substituted indazole derivatives active as kinase inhibitors US Patent  US9408850 Publication Date 8/9/2016 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3 [564-993]
Synonyms:
CD135 | FLK2 | FLT3 | FLT3_HUMAN | Receptor-type tyrosine-protein kinase FLT3 | STK1
Type:
Protein
Mol. Mass.:
49684.10
Organism:
Homo sapiens (Human)
Description:
aa 564-993
Residue:
430
Sequence:
HKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
  
Inhibitor
Name:
BDBM239042
Synonyms:
US10028934, Compound 42 | US10478423, Cpd. 42 | US9408850, 42 | US9597317, 42
Type:
Small organic molecule
Emp. Form.:
C29H30F3N5O4
Mol. Mass.:
569.5748
SMILES:
C[N+]1([O-])CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(cc3)C(F)(F)F)ccc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BioDB n*24 SEQ ID NO: 1
Synonyms:
n/a
Type:
Peptide Substrate
Mol. Mass.:
2821.27
Organism:
Artificial Organism
Description:
SEQ ID NO: 1
Residue:
25
Sequence:
GGKKKVSRSGLYRSPSMPENLNRPR