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Target
Mast/stem cell growth factor receptor Kit [544-976]
Ligand
BDBM239014
Substrate
BioDB n*138 SEQ ID NO: 2
Meas. Tech.
Biochemical Assay
pH
7.9±n/a
IC50
564±n/a nM
Comments
extracted
Citation
 Lombardi Borgia, A; Ciomei, M; Donati, D; Nesi, M Substituted indazole derivatives active as kinase inhibitors US Patent  US9408850 Publication Date 8/9/2016 
Target
Name:
Mast/stem cell growth factor receptor Kit [544-976]
Synonyms:
KIT | KIT_HUMAN | SCFR | Tyrosine-protein kinase Kit
Type:
Protein
Mol. Mass.:
48998.23
Organism:
Homo sapiens (Human)
Description:
aa 544-976
Residue:
433
Sequence:
TYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV
  
Inhibitor
Name:
BDBM239014
Synonyms:
US10028934, Compound 3 | US10478423, Cpd. 3 | US9408850, 3 | US9597317, 3
Type:
Small organic molecule
Emp. Form.:
C25H24FN5O2
Mol. Mass.:
445.4888
SMILES:
CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(Oc3cccc(F)c3)ccc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BioDB n*138 SEQ ID NO: 2
Synonyms:
n/a
Type:
Peptide Substrate
Mol. Mass.:
3822.64
Organism:
Artificial Organism
Description:
SEQ ID NO: 2
Residue:
30
Sequence:
KWEEINGNNYVYIDPTQLPYDHKWEFPRNR