Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM239074
Substrate
n/a
Meas. Tech.
[35S]GTPγS Binding Assay
Temperature
303.15±n/a K
EC50
112.9±29.2 nM
Comments
extracted
Citation
 Prather, PL; Prisinzano, TE; Fantegrossi, WE; Brents, LK; Moran, J; Radominska-Pandya, A; Vasiljevik, T Use of the aminoalkylindole JWH-073-M4 and related compounds as neutral CB1 receptor antagonists for the treatment of alcoholism, drug abuse, obesity, and obesity-related diseases US Patent  US9416103 Publication Date 8/16/2016 
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_MOUSE | Cannabinoid CB1 receptor | Cannabinoid receptor | Cnr1
Type:
Enzyme
Mol. Mass.:
52842.52
Organism:
Mus musculus (Mouse)
Description:
P47746
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEDNIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM239074
Synonyms:
US9416103, JWH-073-M1
Type:
Small organic molecule
Emp. Form.:
C23H21NO2
Mol. Mass.:
343.4183
SMILES:
CCCCn1cc(C(=O)c2cccc3ccccc23)c2c(O)cccc12
Structure:
Search PDB for entries with ligand similarity: