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Target
Angiopoietin-1 receptor [776-1124]
Ligand
BDBM239573
Substrate
n/a
Meas. Tech.
Sandwich ELISA Assay
pH
9.6±n/a
Temperature
277.15±n/a K
IC50
3.0±n/a nM
Comments
extracted
Citation
 Süβmeier, F; Lobell, M; Grünewald, S; Härter, M; Buchmann, B; Telser, J; Jöriβen, H; Heroult, M; Kahnert, A; Lustig, K; Lindner, N Substituted phenylimidazopyrazoles and their use US Patent  US9394309 Publication Date 7/19/2016 
Target
Name:
Angiopoietin-1 receptor [776-1124]
Synonyms:
TEK | TIE2 | TIE2_HUMAN | Tyrosine-protein kinase receptor TIE-2 | VMCM | VMCM1
Type:
Enzyme
Mol. Mass.:
39865.58
Organism:
Homo sapiens (Human)
Description:
amino acids 776-1124
Residue:
349
Sequence:
NVQRRMAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
  
Inhibitor
Name:
BDBM239573
Synonyms:
US9394309, 26
Type:
Small organic molecule
Emp. Form.:
C25H20F5N5O3S2
Mol. Mass.:
597.58
SMILES:
Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)S(C)(=O)=O)cc1-n1ccn2nc(cc12)-c1cccnc1
Structure:
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