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Target
Nociceptin receptor
Ligand
BDBM239901
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
34.5±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM239901
Synonyms:
US9403767, 64 | US9403767, 65
Type:
Small organic molecule
Emp. Form.:
C30H40N2O
Mol. Mass.:
444.6514
SMILES:
CN(C)C1(CC2CCCC2)CCC(CC1)(N(C)C(=O)\C=C\c1ccccc1)c1ccccc1 |(6.46,1.19,;6.57,-.35,;5.29,-1.21,;7.95,-1.02,;6.62,-1.79,;6.62,-3.33,;7.86,-4.24,;7.39,-5.7,;5.85,-5.7,;5.37,-4.24,;8.77,-2.33,;10.31,-2.27,;11.03,-.91,;10.21,.39,;8.67,.34,;12.36,-.14,;13.89,.02,;12.36,1.4,;13.7,2.17,;11.03,2.17,;11.03,3.71,;9.7,4.48,;8.36,3.71,;7.03,4.48,;7.03,6.02,;8.36,6.79,;9.7,6.02,;12.41,-1.59,;13.69,-.73,;15.07,-1.4,;15.18,-2.94,;13.91,-3.8,;12.52,-3.13,)|
Structure:
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