Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM239917
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
5.35±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM239917
Synonyms:
US9403767, 91
Type:
Small organic molecule
Emp. Form.:
C32H38N6O2
Mol. Mass.:
538.6831
SMILES:
CNc1nc(Oc2ccc(OC)cc2)nc(n1)N(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1 |(2.16,-6.79,;1.44,-8.15,;2.26,-9.46,;1.53,-10.81,;2.35,-12.12,;1.63,-13.48,;.09,-13.53,;-.64,-14.89,;-2.17,-14.95,;-2.99,-13.64,;-4.53,-13.7,;-5.25,-15.06,;-2.27,-12.28,;-.73,-12.23,;3.89,-12.07,;4.61,-10.71,;3.8,-9.4,;6.15,-10.65,;6.04,-12.19,;6.87,-9.29,;8.21,-8.52,;8.21,-6.98,;6.87,-6.21,;5.54,-6.98,;5.54,-8.52,;6.15,-4.85,;4.61,-4.8,;6.04,-3.32,;7.6,-4.85,;6.78,-3.55,;7.5,-2.19,;9.04,-2.13,;9.86,-3.44,;9.14,-4.8,;7.6,-10.65,;9.14,-10.71,;9.86,-12.07,;9.04,-13.37,;7.5,-13.32,;6.78,-11.96,)|
Structure:
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